Phenylpropanoids and polyketides
Medchemexpress LLC SAR405 R enantiomer | 1946010-79-2 | 99.9% | 443.85 | C19H21ClF3N5O2 | 10MG
SAR405 R enantiomer is the less active stereoisomer of the PIK3C3/Vps34 inhibitor SAR405, provided as a solid for in vitro research use only. It is suited for comparative pharmacology and control studies and includes handling and storage guidance for reliable experimental use.
- Less active enantiomer used as a comparative control in assays.
- High purity (≈99.9%).
- Solid, white to off-white appearance.
- Molecular formula C19H21ClF3N5O2; molecular weight 443.85.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store powder at -20°C for long-term stability; store solutions at -80°C.
- Intended for laboratory research use only.
Apexbio Technology LLC Entacapone 130929-57-6 10mM (in 1mL DMSO)
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
Medchemexpress LLC Ozagrel hydrochloride | 78712-43-3 | MFCD06795644 | >98.0% | 10 MG
Ozagrel hydrochloride is the hydrochloride salt of ozagrel, a selective thromboxane A2 (TXA2) synthase inhibitor used in preclinical research to study platelet aggregation, ischemic stroke, asthma, and thromboembolic disease.
- Selective thromboxane A2 (TXA2) synthase inhibitor with reported IC50 ~11 nM.
- Reduces thromboxane A2 production, leading to anti-platelet aggregation and vasodilation.
- Hydrochloride salt supplied as a powder suitable for in vitro and in vivo research.
- Typical molecular weight 264.71 g/mol and formula C13H13ClN2O2.
- High purity commonly reported as ≥98% (verify with vendor for specific lot).
- Store powder at -20°C for long-term stability; in solution, store at -80°C.
Selleck Chemical LLC BLU 451-E1877-25MG
BLU 451 is a central nervous system (CNS)-penetrant wild-type EGFR-sparing covalent inhibitor of epidermal growth factor receptor (EGFR) exon 20 insertion (Ex20ins) with an IC50 of 7-78 nM It also exhibits a potent anti-tumor efficacy